Dual SGLT-1 and SGLT-2 inhibition improves left atrial dysfunction in HFpEF
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چکیده
منابع مشابه
SGLT-2 inhibition in patients with kidney disease.
Accustomed to managing diabetes with agents that mostly act by modulating the secretion and actions of insulin, with the advent of sodium-glucose linked transporter-2 (SGLT-2) inhibitors, physicians are now aware that the kidney also needs to be considered in the spectrum of action of anti-hyperglycaemic agents. Though familiar with the need for dose adjustment when prescribing many of our curr...
متن کاملThe Renal Hemodynamic Effect of SGLT 2 Inhibition in Patients with Type 1 Diabetes
Dept of Medicine, Division of Nephrology; Dept of Medicine, Division of Endocrinology, Toronto General Hospital, University of Toronto, Toronto, Canada; Boehringer Ingelheim Canada Ltd./Ltée, Burlington, Canada; Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT; Boehringer Ingelheim Pharma GmbH & Co.KG, Ingelheim, Germany *contributed equally as primary co-authors; †contributed equally...
متن کاملThe Renal Hemodynamic Effect of SGLT 2 Inhibition in Patients with Type 1 Diabetes Running title :
Dept of Medicine, Division of Nephrology; Dept of Medicine, Division of Endocrinology, Toronto General Hospital, University of Toronto, Toronto, Canada; Boehringer Ingelheim Canada Ltd./Ltée, Burlington, Canada; Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT; Boehringer Ingelheim Pharma GmbH & Co.KG, Ingelheim, Germany *contributed equally as primary co-authors; †contributed equally...
متن کاملThe Human Kidney Low Affinity Na + / glucose Cotransporter SGLT 2
The major reabsorptive mechanism for D-glucose in the kidney is known to involve a low affinity high capacity Na+/glucose cotransporter, which is located in the early proximal convoluted tubule segment S1, and which has a Na' to glucose coupling ratio of 1:1. Here we provide the first molecular evidence for this renal D-glucose reabsorptive mechanism. We report the characterization of a previou...
متن کاملHormonal regulation of chicken intestinal NHE and SGLT-1 activities.
The effects of aldosterone and arginine vasotocin (AVT) on intestinal Na(+)/H(+) exchange (NHE) and Na(+)-sugar cotransport (SGLT-1) activities have been investigated using brush-border membrane vesicles isolated from Hubbard chicken small and large intestines, and they were compared with those induced by either Na(+) depletion or dehydration. Na(+) depletion was induced by feeding the chickens...
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ژورنال
عنوان ژورنال: Cardiovascular Diabetology
سال: 2021
ISSN: 1475-2840
DOI: 10.1186/s12933-020-01208-z